Tottenham qualified for the last 16 as Group A winners in their maiden Champions League season.
Tottenham, whose three goals came courtesy of a freak Peter Wisgerhof own goal and two from England striker Jermain Defoe on his first start in the competition, closed with 11 points as well as 18 goals.
Twente responded through Roberto Rosales, Nacer Chadli and Denny Landzaat to take third spot and a Europa League berth.
Inter Milan, meanwhile, slipped up in dramatic fashion against Werder Bremen.
A first-half header from Sebastien Prodl combined with a glorious volley from former Inter man Marko Arnautovic and a sharp strike from substitute Claudio Pizarro after the break earned Bremen their first win in the group.
It could have been even more emphatic for the Germans who hit the post and the bar as they carved open the defending champions in the second half.
FC Copenhagen stormed into the knockout stage with a 3-1 defeat of Panathinaikos apart at the Parken.
Martin Vingaard put the hosts ahead in the 26th minute and from then on they were dominant, with a 50th-minute penalty from Jesper Gronkjaer and Djibril Cisse's own goal wrapping up the points, before Cedric Kante netted late on for Pana.
The result ensured Copenhagen advanced from Group D in second place, though Barcelona's win over Rubin Kazan meant they would have gone through regardless.
A largely second-string Barca consigned Rubin to a place in the Europa League after securing a 2-0 win at the Nou Camp.
Andreu Fontas' deflected second-half effort and a late Victor Vazquez strike earned already-qualified Barca their fourth win in Group D.
Manchester United lost their perfect Champions League defensive record to Valencia but still managed to claim top spot in Group C thanks to Anderson's second-half equaliser in a 1-1 draw.
Pablo Hernandez rifled the visitors in front after half an hour before Brazilian Anderson notched just his second Red Devils goal after 62 minutes.
Kenny Miller scored his 19th goal of the season but third-placed Rangers could only conclude their campaign with a draw against Bursaspor in the Ataturk stadium.
The Ibrox striker broke the deadlock in the 19th minute when he lashed a left-footed shot from 12 yards past Yavuz Ozkam, however, the Scottish champions were forced to defend for most of the second half and in the 79th minute Sercan Yildirim stabbed the ball past Allan McGregor to give the Turkish club their first point.
Schalke secured top spot in Group B with a 2-1 victory away to hapless Benfica.
Having already sealed their passage to the knockout stage thanks to a 3-0 win over Lyon a fortnight ago, goals by Jose Manuel Jurado and Benedikt Howedes, before Luisao's consolation, gave them the win required to qualify as winners.
Benfica made the Europa League anyway after Hapoel Tel Aviv succumbed to a late Alexandre Lacazette equaliser to draw 2-2 with the Ligue 1 side.
After an entertaining but goalless first half Lisandro Lopez and Ben Sahar traded goals within a minute of each other around the hour mark before Eran Zahavi made it 2-1 to the visitors.
That would have been enough for third place and a parachute into the last 32 of the Europa League, but Lacazette popped up late on.
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